胸部CT和MRI对胸段食管癌淋巴结转移的诊断价值

目的 比较胸部计算机断层扫描（computer tomography,CT）和磁共振成像（magnetic resonance imaging,MRI）判断胸段食管癌淋巴结转移的临床价值。方法 回顾性分析2015年7月—2019年6月在我院诊治的胸段食管癌淋巴结转移患者90例,所有患者在入院后均采用胸部CT和MRI平扫及增强扫描,并在手术后对病灶组织标本进行病理学检测,以病理诊断结果为金标准,分析胸部CT和MRI灵敏度和特异度。结果 MRI扫描,灵敏度为88.73%,特异度为94.74%,阳性预测值为98.44%,阴性预测值为69.23%,高于胸部CT扫描的69.01%、52.63%、84.48%、31.25%。淋巴结转移分布中,胸中段最多,胸上段、胸中段、胸下段所占比例分别为26.67%、60.00%、13.33%,胸上段中最上纵隔和气管旁淋巴结转移最多,胸中段气管旁、隆突下淋巴结转移最多,胸下段贲门旁、胃左动脉旁淋巴结转移最多,MRI诊断准确率高于胸部CT。结论 胸部CT、MRI均能够诊断出胸段食管癌淋巴结转移,MRI诊断胸段食管癌淋巴结转移的诊断价值优于胸部CT,MRI在胸段淋巴结各部位的诊断准确率高于胸部CT,能够更清晰显示淋巴结的转移情况。     

Matrix metalloproteinase-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer

Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a novel membrane-anchored matrix metalloproteinase (MMP) inhibitor. RECK, MMP-2, and MMP-9 are believed to play crucial roles in tumor progression. This study was designed to examine the prognostic value of RECK, MMP-2, and MMP-9 in conjunction with other clinicopathologic factors in patients of T3-T4 node-negative colorectal cancer. RECK and MMP expression was observed using immunohistochemical analysis of the primary tumor from 89 patients with curatively resected T3-4 N0 colorectal cancer retrospectively. High RECK expression was observed in 51 cases, whereas expression was low in the other 38 cases. MMP-2 and MMP-9 expression was positive in cancer cells in 24 and 33 cases, respectively. RECK and MMP-2 expression was not significantly associated with any clinicopathologic factors. However, expression of MMP-9 was correlated with tumor location. A statistically significant inverse correlation was found between RECK and MMP-2 expression, and a statistically significant correlation was found between MMP-2 and MMP-9 expression. However, no association between RECK and MMP-9 expression was observed. Univariate analysis demonstrated that rectal tumor location, preoperative carcinoembryonic antigen more than 5 ng/mL, positive lymphatic invasion, less than 12 dissected lymph nodes, and positive MMP-9 expression were poor prognostic factors of disease-free survival. A multivariate analysis confirmed that enhanced MMP-9 expression was an independent and significant factor for prediction of a poor prognosis. In addition, positive lymphatic invasion and less than 12 dissected lymph nodes were significant negative prognostic factors. In conclusion, MMP-9 status represents a novel prognostic factor in evaluation of T3-T4 node-negative colorectal cancer.     

皮肤阻抗等效电路及经络低阻抗原因探讨

将矩形波电压通过两点电极加到人体皮肤表面，得到的电流波形是一些尖脉冲。经络线上的电流波形与非经络线上的波形有差别，表现为低电阻，高电容现象。产生高电容现象的机理目前尚不清楚。本文提出了一个等效电路并探讨了产生高电容现象的原因。     

Spatial deployment of attention within and across hemifields in an auditory task

Research on visual attention has demonstrated that covert attention can be focused on particular locations within one hemifield, but that a specific "meridian" cost may also be found for shifting attention between hemifields. These issues have received less consideration for audition, even though reliable behavioral measures for the effects of spatial attention on hearing are now available. We examined the spatial distribution of covert attention in an auditory task following spatially non-predictive peripheral auditory cues (which should induce exogenous attention shifts), or following symbolic central cues that predicted the likely location for the auditory target (to induce endogenous attention shifts). In both cases, we found that attention can be focused not only on one hemifield versus another, but also within one hemifield in an auditory task. However, there was no unequivocal evidence for a meridian effect in audition. Electronic Publication     

智能化穴位温度检测仪的研制及实验研究

在经络穴位的生物物理属性中，由于皮肤温度比较灵敏，易于观察，又能及时反映该处血管的舒缩变化。作者利用铂电阻作为测温控头，用微机进行数据处理，并利用该系统进行人体皮肤温度的检测及分析。结果表明：皮肤温差点基本上是循经分布的。     

血管树拓扑描述及匹配方法的研究

血管树的拓扑描述及匹配是由二维血管造影图像重建三维血管树的关键步骤,我们采用二叉树描述二维血管骨架树,提出“结点权值”和“相似结点”的概念,很好地描述了血管树的拓扑结构。同时根据二叉树的前序遍历结果匹配血管段,有效地提高了匹配的速度和准确度。     

小型中医经络检测仪的研制

在传统中医经络理论的基础上，结合先进的电子技术设备，设计了一种小型中医经络检测仪。此检测仪通过采集人体穴位经电流测试(给一定电流刺激)所反射出来的信息，经微控制器处理后，能够精确显示或打印出人体的健康状况。检测仪具有方便、快捷等优势，易推广普及。     

~(32)P放射自显影术对家兔经脉循行路线的宏观显示

目的对家兔经脉循行路线进行宏观显示的研究,为细胞水平及超微组织结构的示踪研究奠定基础。方法用穴位测定治疗仪在对应人体的外关、内关、昆仑、太溪经穴处对家兔的经穴定位,经穴位注入Na2H32PO4,用32P整体放射自显影术对家兔经脉循行路线进行宏观显示。结果获得了家兔经脉循行路线整体放射自显影像,影像线性较宽,形状单一且较粗大,影像走向与通过家兔皮肤导电量测定获得的经穴走向相似。结论家兔体表存在与人体相近的具有低阻抗性的经穴,32P放射自显影术可以实现家兔经脉循行路线的宏观显示。     

电针心经腧穴对急性心肌缺血大鼠自主神经活动的影响

目的:观察电针心经"神门-通里"经脉段对急性心肌缺血大鼠交感神经和迷走神经放电的影响,探讨两者在电针心经改善急性心肌缺血中的协同调节作用。方法:SD大鼠随机分为伪手术组、模型组和电针心经组,每组10只。冠状动脉左前降支结扎法复制大鼠急性心肌缺血模型。电针心经组给予电针刺激大鼠心经"神门-通里"经脉段,刺激20min。用两根铂金丝电极分别同步引导左侧交感神经和迷走神经,同时记录模型复制前5min,结扎后即刻,电针后1、3、5、15 min的心电图、交感神经和迷走神经放电频率。结果:急性心肌缺血模型复制后,与伪手术组比较,模型组大鼠各时相心率、心电图J点电压、交感神经放电频率显著升高(P0.01),迷走神经放电频率显著降低(P0.01);与模型组比较,电针心经组大鼠各时相心率、心电图J点电压、交感神经放电频率均显著降低(P0.01),迷走神经放电频率显著升高(P0.01)。结论:电针心经可通过同时抑制交感神经放电和促进迷走神经放电,发挥改善急性心肌缺血的协同调节作用。     

经筋辨证敷贴疗法对膝关节镜术后温度及疼痛的影响

[目的]比较经筋辨证敷贴疗法对膝关节镜术后结筋病灶点红外温度和疼痛的影响。[方法]选取2018年6—12月在本科收治的60例行膝关节镜的患者随机分成对照组和试验组,各30例,在常规护理的基础上,对照组术后采用常规敷贴疗法进行护理,试验组术后采用经筋辨证敷贴疗法进行护理,观察两组患者术前、术后14 d及28 d疼痛视觉模拟(VAS)评分,委阳次、阴陵上、足三里次、髌内下四处结筋病灶点红外温度。[结果]两组术后4处结筋病灶点红外温度均较术前降低,两组术后VAS疼痛评分均较术前明显下降(P0.05)。试验组术后4处结筋病灶点红外温度低于对照组(P0.05),试验组术后VAS疼痛评分均低于对照组。[结论]经筋辨证敷贴疗法能明显缓解膝关节镜患者疼痛的症状,可改善膝关节镜术后经筋病灶点红外温度,红外温度的变化可为疼痛的缓解提供客观而直接的评价依据。